b) Fetal hemoglobin has a higher affinity for oxygen than adult hemoglobin.
Feedback:
The blood in the umbilical vein is about 80% saturated with O2. Fetal blood has a higher hemoglobin content than adult blood and fetal hemoglobin has a higher affinity for O2 than adult hemoglobin. The O2 content of blood in the umbilical vein is therefore about 160 ml/l. As the blood perfusing the brain is supplied via the ascending aorta and as the ductus arteriosus supplies deoxygenated blood to the descending aorta, the blood perfusing the brain has a higher PO2 than that of the descending aorta.
Question 2
Regarding the fetal circulation:
Correct answer:
a) The fetal heart rate is nearly double that of a healthy adult.
Feedback:
Because of the operation of the crista dividens, most of the blood returning in the umbilical vein passes directly to the left atrium via the foramen ovale. The fetal shunts normally close in the first few days after birth. Fetal blood pressure is normally low (c. 70/45 mm Hg).
Question 3
Regarding respiration in the fetus and newborn:
Correct answer:
d) The first breath is achieved by large changes in the intrathoracic pressure.
Feedback:
The central chemoreceptors are active but not the peripheral chemoreceptors which become progressively more sensitive in the weeks following birth. Although the proportion of the right ventricular output passing through the lungs greatly increases after the first breath, it is some days before closure of the ductus arteriosus results in all of the blood from the right ventricle passing through the lungs. Lack of surfactant in the neonate may cause respiratory distress.
Question 4
Regarding the function of the fetal adrenal glands and kidneys:.
Correct answer:
c) The kidneys play an important role in the regulation of acid-base balance of the fetus.
Feedback:
Fetal cortisol stimulates the production of pulmonary surfactant by alveolar type II cells. The fetal zone of the adrenal gland synthesizes large amounts of estrogen precursors which are converted to estrogenic hormones by the placenta. The fetal kidneys produce a hypotonic urine after about 8 weeks gestation Page reference: 486-487
Question 5
Regarding the sexual development of the fetus:
Correct answer:
a) The sex of an individual is determined by a single gene on the Y chromosome.
Feedback:
The sex of an individual is determined by a single gene on the Y chromosome. In the absence of a Y chromosome the development of the gonads will follow the female pattern. The development of male sex organs depends on the presence of testosterone. In the absence of testosterone, development follows the female pattern.
1.
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