TRUE OR FALSE
Haematology
1. Platelets:
a. Have a circulation lifespan of 10 hours in healthy subjects.
b. Are produced and regulated under the control of thrombopoietins.
c. Contain small nuclear remnants called Howell-Jolly bodies.
d. Decrease in number in response to aspirin therapy.
e. Release serotonin and von Wiliebrand factor (vWF).
2. Some features of the beta-thalassaemlas Include:
a. Macrocytic anaemia
b. Hepatosplenomegaly
c. Pigment gall stones
d. Neonatal hemolytic anemia
e. Chronic leg ulceration.
3. Pernicious Anemia is characterized by:
a. Macrocytic anemia
b. Pyramidal lesions
c. Splenomegaly
d. Deep sensory loss
e. Cerebellar ataxia
4. Hypochromic microcytic anaemia is a recognised finding in
a. haemolytic anaemia
b. primary sideroblastic anaemia
c. hypothyroidism
d. beta-thalassaemia
e. rheumatoid arthritis
5. Typical haematological findings in megaloblastic anaemia include
a. pancytopenia and oval macrocytosis
b. neutrophil leucocyte hypersegmentation
c. anisocytosis and poikilocytosis
d. reticulocytosis and polychromasia
e. excess urinary urobilinogen and bilirubinuria
6. Haemolytic anaemia is a recognized complication of
a. prosthetic heart valves
b. mycoplasma pneumonia
c. megaloblastic anaemia
d. malarial infection
e. sulphonamide therapy
7. The typical features of autoimmune haemolytic anaemia include
a. peripheral blood spherocytosis and polychromasia
b. fever with haemoglobinuria and haemosiderinuria
c. association with systemic lupus erythematosus
d. positive Coomb's antiglobulin test and splenomegaly
e. association with lymphoproliferative disease
8. The typical features of polycythaemia rubra vera include
a. predominance in females aged < 40 years
b. splenomegaly, leucocytosis and thrombocytosis
c. headaches, pruritus and peptic ulcer dyspepsia
d. decreased leucocyte alkaline phosphatase score
e. increased blood viscosity associated with vascular disease
9. Recognised causes of neutropenia and agranulocytosis include
a. folic acid deficiency
b. sulphasalazine therapy
c. sickle-cell anaemia
d. infectious mononucleosis
e. carbimazole therapy
10. Peripheral blood neutrophil leucocytosis is an expected finding in
a. connective tissue disease
b. corticosteroid therapy
c. pregnancy
d. whooping cough
e. mesenteric infarction
11. Acute lymphoblastic leukaemia
a. usually develops in patients > 20 years old
b. typically produces blast cell cytoplasmic Auer rods
c. responds better to chemotherapy than other acute leukaemias
d. is the most common of all acute leukaemias
e. is a typical complication of multiple myeloma
12. The typical laboratory findings In chronic myelold leukaemia Include
a. leucoerythroblastic anaemia and thrombocytosis
b. peripheral blood neutrophilia, eoslnophitia and basophilia
c. chromosomal translocation 22q/9q in 90% of patients
d. Increased neutrophil leucocyte alkaline phosphatase score
e. transformation to acute lymphoblastic leukaemia
13. Typical features of chronic lymphatic leukaemia include
a. onset in younger patients than in CIVIL
b. development of autoimmune haemolyficanaemia
c. presentation with massive hepatosplenomegaly and anaemia
d. lymphadenopathy associated with recurrent infections
e. median survival of 10 years following chemotherapy
14. The presence of lymphadenopathy and splenomegaly is typical in
a. multiple myeloma
b. chronic lymphatic leukaemia
c. chronic myeloid leukaemia
d. infectious mononucleosis
e. myelofibrosis
15. Recognised clinical features of multiple myeloma Include
a. peak incidence between the ages 60 and 70 years
b. amyloidosis with Bence-Jones proteinuria
c. median survival of 2 years despite chemotherapy
d. recurrent infections and pancytopenia
e. increased serum calcium, urate and blood viscosity
16. Typical histopathological features of Hodgkin's disease Include
a. Reed-Sternberg binucleate giant cells and lymphocytes
b. increased tissue eosinophils, neutrophils and plasma cells
c. increased fibrous strema in the nodular sclerosing type
d. frequent involvement of the central nervous system
e. splenic involvement is rare in the absence of splenomegaly
17. The bleeding time Is characteristically prolonged in
a. Iscorbic acid deficiency
b. thrombocytopenia
c. haemophilia
d. warfarin therapy
e. von Willebrand's disease
18. Recognised causes of thrombocytosis include
a. myeloproliferative disorders
b. iron deficiency anaemia
c. hypersplenism
d. carcinomatosis
e. connective tissue disorders
19. Typical features of idiopathic thrombocytopenic purpura include
a. IgG-mediated thrombocytopenia
b. predominantly affects patients > 40 years old
c. prolongation of the bleeding time
d. palpable splenomegaly
SECTION B: Only one Item appropriately applies to the Statement.
20. Huge splenomegaly is Ane of the typical clinical presentations of
a. Acute myeloid leukemia
b. Acute lymphatic leukemia
c. Chronic myeloid leukemia
d. Typhoid fever
e. All of the above
21. The commonest form of leukemia is
a. Acute myeloid leukemia
b. Acute lymphatic leukemia
c. Chronic myeloid leukemia
d. Chronic lymphatic leukemia
e. Aleukemic leukemia
22. Regarding the Philadelphia chromosome, which one of the following is true
a. Usually found in patient with acute leukemia
b. Rarely found in chronic myeloid leukemia
c. Its presence in acute lymphatic leukemia carries a poor prognosis
d. Usually found in chronic lumphatic leukemia
e. All of the above
23. Which of the following Is false
a. Leukostatic syndrome is a medical emergency
b. Interferone can be used in the treatment of chronic myeloid leukemia
c. Cytogenetic analysis is an important part in the initial work up of any acute leukemia
d. Chronic lymphatic leukemia is rarely discovered accidentally in an asymptomatic patients
e. Gum hyperphasia occurs in CLL
24. CNS prophylaxis Is an essential part In the management of patient with
a. Acute lymphatic leukemia
b. Acute myeloid leukemia
c. Chronic myeloid leukemia
d. Chronic lymphatic leukemia
e. Promyelocyitic anemia
25. Enlarged upper deep cervical lymph nodes:
a. Characteristically raise the lobule of the ear
b. They move with deglutition
c. Are felt deep to the omohyoid muscle
d. Are palpable behind the carotid pulsations
e. All of the above
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